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We have an old 3 arm imitation candelabra light fitting and are now using our last incandescent 60 watt twisted candle bulbs. These sit in a 4cm white plastic sleeve. (Have taken a photo but can't see how to post it).

Can anyone suggest an LED bulb that could be a vaguely suitable replacement? Can LED bulbs be mounted upwards?

My wife suffers with glaucoma and needs very bright lights She has a specialised standard light but an overall brighter room light would be helpful - 100watt equivalents would be a bonus.

LED lamps will work in any orientation, it is your choice which lamps you get, but I would suggest a known brand will last longer as opposed to an "own brand" lamp. If you see one that says "cool white" that may be better for your wife as they are white, but with a hint of blue, making them look brighter.
I have a Phillips hue LED lamp (not cheap) that can be warm white (white with a dose of yellow) or it can be cool white (as described) The cool white definitely looks brighter.

I have struggled, my living room had a single 100 watt tungsten and I do have a few 100 pearl left but realised needed to move to led. That means around 20 watt LED and in the high street largest LED with BA22d fitting is around 15 watt and unlike the tungsten there is very little light shining towards the base. I find the furniture and floor absorb the light where the ceiling reflects it reasonably well so bulbs with base at bottom seem to work better. But the LED is not as bright so needs more area, from internet there are some larger bulbs found at 20 watt but since a good bulb will last years you don't really want a stock, when the bulb fails then you buy new, so you want one you can get in local shops, and I have found the well know makes like Philips are expensive and no better than other high street makes, not talking about internet some from internet are dangerous, and short life, but the high street seems to select reasonable quality so B&M Bargains, HomeBase and the like all do a good range.

So I ended up with a slide in ceiling rose as the chandelier was heavy, and holding weight and wiring up no fun, and an 8 bulb model so a good spread, with 6 watt SES (E14) candle bulbs, so 48 watt in all, around 4000 lumen, the smaller the bulb the less efficient, the tungsten 100W is claimed at 1300 lumen and yes brighter but would not say twice as bright.

It was same in old house went from three bulb chandelier to five bulb to get the extra light, and my son has that house now, in kitchen I had a 65 watt fluorescent these stopped being made so I fitted a 24 watt LED tube, far less light 5800 lumen approx to 2200 lumen, so my son has converter to GU10 lamps, think he has 12, but we were working it out, total wattage same as fluorescent and total lumen same as fluorescent and projected life of fluorescent with a HF ballast is about the same as LED so LED may look better, clearly more expensive but no better than the old fluorescent tube they replaced.

As to tungsten they also heated the room, so with tungsten lights the central heating was set to 18 degrees C all day, but with LED needed a programmable thermostat so 18 in the day and 21 in the evening so no real saving in energy as had to turn up central heating to compensate for loss of radiant heat from bulbs (which the thermostat does not measure) however since heating gas and lighting electric it does save money in long run, after you have paid for new programmable thermostat, since heat from bulb instant likely the bulb uses less energy to central heating, so LED are not energy saving, they may save money, but not energy when used inside the house.